Role of lubricin and boundary lubrication in the


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Role of lubricin and boundary lubrication in the ....

Osteoarthritis is a complex disease involving the mechanical breakdown of articular cartilage in the presence of altered joint mechanics and chondrocyte death, but the connection between these factors is not well established. Lubricin, a mucinous glycoprotein encoded by the PRG4 gene, provides boundary lubrication in articular joints. Joint friction is elevated and accompanied by accelerated ...

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Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis. Author Kimberly A Waller, Ling X Zhang, Khaled A Elsaid, Braden C Fleming, Matthew L ...

PNAS揭示关节炎防治新方法 - 生物...

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis Osteoarthritis is a complex disease involving the mechanical breakdown of articular ...

Regulation of lubricin for functional cartilage tissue ....

Structure and functional role of lubricin. Lubricin, a product of the proteoglycan 4 (PRG4) gene, is highly expressed by synoviocytes and superficial zone chondrocytes [].Lubricin, generally known as a proteoglycan, is a glycoprotein that functions as a critical boundary lubricant for articular cartilage and normally isolated from synovial fluid [].

Role of lubricin and boundary lubrication in the ....

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis Article in Proceedings of the National Academy of Sciences 110(15) · March 2013 with 30 Reads

Conformational Mechanics, Adsorption, and Normal Force ....

Glycoproteins, such as lubricin, and hyaluronic acid (HA) play a prominent role in the boundary lubrication mechanism in diarthrodial joints. Although many studies have tried to elucidate the lubrication mechanisms of articular cartilage, the molecular details of how lubricin and HA interact with cartilage surfaces and mediate their interaction still remain poorly understood.

Galectin-3 Binds to Lubricin and Reinforces the ....

Effective boundary lubrication by lubricin is dependent upon both its ability to adsorb to articular cartilage 11,12 and the presence of O-linked β(1–3)Gal-GalNAc oligosaccharides 13; however ...

Synthesis and characterization of a lubricin mimic (mLub ....

the lubricin is associated with cartilage degradation and the pathogenesis of OA3. Lubricin creates boundary lubrication, characterized as a molecular thin film between sliding surfaces in order to reduce friction and wear4. Animal models of joint injury have also shown treatment with lubricin has resulted in a reduction of cartilage degradation5.

Regulation of lubricin for functional cartilage tissue ....

lubricin is verified to carry its responsibility for antag-onizing abnormal cellular adhesion and overgrowth. The fundamental role of lubricin is lubrication of boundary surface of cartilage [18]. Hence, transmuta-tion of lubricin metabolism would conspicuously influ-ence joint performance. In fact, patients who suffer

Role of lubricin and boundary lubrication in the ....

Lubricin, a mucinous glycoprotein produced by synovial cells and superficial zone chondrocytes (11, 14), provides lubrication in the boundary mode . Boundary lubrication dominates during periods of high load and low velocity, when the lubricant film layer is thinner than the surface roughness .

Role of lubricin and boundary lubrication in the ....

Lubricin, a mucinous glycoprotein encoded by the PRG4 gene, provides boundary lubrication in articular joints. Joint friction is elevated and accompanied by accelerated cartilage damage in humans and mice that have genetic deficiency of lubricin.

Boundary mode lubrication of articular cartilage by ....

Lubrication of cartilage involves a variety of physical and chemical factors, including lubricin, a synovial glycoprotein that has been shown to be a boundary lubricant. It is unclear how lubricin boundary lubricates a wide range of bearings from tissue to artificial surfaces, and if the mechanism is the same for both soluble and bound lubricin.

The biology of Lubricin: Near frictionless joint motion ....

Lubricin is a surface-active mucinous glycoprotein secreted in the synovial joint that plays an important role in cartilage integrity. In healthy joints, lubricin molecules coat the cartilage surface, providing boundary lubrication and preventing cell and protein adhesion.

Proteoglycan 4 - Wikiped...

Function. Lubricin is present in synovial fluid and on the surface (superficial layer) of articular cartilage and therefore plays an important role in joint lubrication and synovial homeostasis.When first isolated, cartilage lubricin was called "superficial zone protein" (SZP). Lubricin, MSF, and SZP are now collectively known as Proteoglycan 4 (hence PRG4 for the gene nomenclature).

The role of lubricin in the mechanical behavior of ....

Synovial fluid is a semidilute hyaluronate (HA) polymer solution, the rheology of which depends on HA-protein interactions, and lubricin is a HA-binding protein found in synovial fluid and at cartilage surfaces, where it contributes to boundary lubrication under load. Individuals with genetic deficiency of lubricin develop precocious joint failure.

The role of lubricin in normal and pathological joint ....

of lubricin, including lubrication and cytoprotection. Lubricin plays an important role in articular joint physiology, and the loss of accumu-lation of lubricin may be a factor in the pathology of osteoarthritis (OA) (Figure 1). Therefore, a recent study8 demonstrated that recombi-nant lubricin has a role in chondro-protection in an animal OA model

Stimulation of Superficial Zone Protein/Lubricin/PRG4 by ....

Superficial zone protein (SZP), also known as lubricin and proteoglycan 4 (PRG4), plays an important role in the boundary lubrication of articular cartilage and is regulated by transforming growth factor (TGF)-β.

The role of lubricin in the mechanical behavior of ....

Synovial fluid is a semidilute hyaluronate (HA) polymer solution, the rheology of which depends on HA–protein interactions, and lubricin is a HA-binding protein found in synovial fluid and at cartilage surfaces, where it contributes to boundary lubrication under load.

The role of lubricin in the ... - PubMed Central (PM...

Therefore, lubricin provides a chondroprotective feature to synovial fluid that is distinct from the role lubricin plays at the cartilage surface as a boundary lubricant. Additional MPTM experiments, which involve reintroducing lubricin to HA in the presence of the synovial protein milieu, are needed.